exacerbation

nouns

action that makes a problem or a disease (or its symptoms) worse
"the aggravation of her condition resulted from lack of care"
aggravation, exacerbation
is derived from
exacerbate
violent and bitter exasperation
"his foolishness was followed by an exacerbation of their quarrel"
exacerbation
is derived from
exacerbate
is a type of (narrower)
actions that cause great irritation (or even anger)
exasperation