aggravation

nouns

an exasperated feeling of annoyance
aggravation, exasperation
is derived from
aggravate
unfriendly behavior that causes anger or resentment
aggravation, irritation, provocation
is derived from
aggravate
action that makes a problem or a disease (or its symptoms) worse
"the aggravation of her condition resulted from lack of care"
aggravation, exacerbation
is derived from
aggravate